
CNDAC hydrochloride
CAS No. 134665-72-8
CNDAC hydrochloride ( —— )
产品货号. M23508 CAS No. 134665-72-8
CNDAC 盐酸盐是一种核苷类似物,是沙帕他滨的代谢物。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2333 | 有现货 |
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10MG | ¥3629 | 有现货 |
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25MG | ¥5986 | 有现货 |
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50MG | ¥7995 | 有现货 |
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100MG | ¥11178 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称CNDAC hydrochloride
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述CNDAC 盐酸盐是一种核苷类似物,是沙帕他滨的代谢物。
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产品描述CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.
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体外实验Cell Viability Assay Cell Line:Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF CHO cellsConcentration:0-1 μMIncubation Time:24 h Result:Inhibited cell survival with IC50s of 0.006, 0.32, 0.48 and 0.0053 μM against Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF cell lines, respectively.Cell Proliferation Assay Cell Line:HL-60 and THP-1 cells Concentration:0-100 μM Incubation Time:3 days Result:Inhibited proliferation with IC50s of 1.5832 μM and 0.84 μM against HL-60 and THP-1 cells, respectively.Apoptosis Analysis Cell Line:HL-60 and THP-1 cells Concentration:0, 0.5, 1, 2, 3, 4, 5 and 10 μM Incubation Time:3, 4, 5, and 6 days Result:Induced apoptosis in both cells.Cell Cycle Analysis Cell Line:HCT116 Concentration:6?μM Incubation Time:48?h Result:36 and 36% of cells were arrested in late-S and G2/M phases, respectively.
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体内实验Animal Model:CDF1 mice, P388 tumor modelDosage:20 mg/kg Administration:Intraperitoneal injection, daily for 10 days Result:Greatly increased the survival time and survival rate.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number134665-72-8
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分子量288.69
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分子式C10H13ClN4O4
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纯度>98% (HPLC)
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溶解度DMSO:123 mg/mL (426.06 mM; Need ultrasonic)
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SMILESCl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2C#N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Liu XJ, et al. Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin J Cancer. 2012 Aug;31(8):373-80.
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